No less an icon than Benjamin Frankin, himself, had a message back in the late 1700's for anti-vaxxers, much to my surprise. See the quote below from his autobiography which he finished very late in his auspicious life:
"In 1736, I lost one of my sons, a fine boy of four years old, to the small pox, taken in the common way. I long regretted bitterly and still regret that I had not given it to him by inoculation. This I mention for the sake of parents who omit that operation on the supposition that they should never forgive themselves if a child died under it; my example showing that the regret may be the same either way, and that, therefore, the safer should be chosen."
Benjamin Franklin
And though the methods back in that day were gruesome, to say the least, Benjamin Franklin makes a point just as valid today.
BTW, it's an awesome autobiography - really well written and compelling - about one of my favorite founding fathers. Full disclosure, I was born in Philly and Ben Franklin is atop city hall. Just love him!